منابع مشابه
Mepolizumab in refractory eosinophilic asthma.
In a recent Lung Alert reviewing our study of mepolizumab in severe eosinophilic asthma, Barratt states that the study population represented a minority of patients with asthma and that they had corticosteroidresistant disease. These comments require clarification. While we accept that the population studied by us represents about 3% of the total asthma population, it was 30% of patients with r...
متن کاملMepolizumab in the treatment of eosinophilic esophagitis
Eosinophilic esophagitis (EE) is a clinical entity characterized by eosinophilic infi ltration limited to the esophageal epithelium without signifi cant eosinophilic infl ammation of the remainder of the upper gastrointestinal tract mucosa. It can occur in isolation or as part of an atopic spectrum together with asthma, allergic rhinitis and/or atopic dermatitis. EE was fi rst described in the ...
متن کاملMepolizumab (Nucala) For Severe Eosinophilic Asthma.
Mepolizumab (Nucala) for severe eosinophilic asthma.
متن کاملClinical usefulness of mepolizumab in severe eosinophilic asthma
Asthma is a chronic inflammatory disorder of the airways with variable clinical severity from very mild and occasional symptoms to recurrent critical exacerbations, at risk of fatal or near-fatal outcome, in a small percentage of patients. Within the different inflammatory cascades involved in asthma, eosinophils play a central role in the pathogenesis and largely influence disease severity. In...
متن کاملMepolizumab treatment in patients with severe eosinophilic asthma.
BACKGROUND Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled glucocorticoids with or without oral glucocorticoids. METHODS In this randomized, double-blind, double-dummy study, we assigned 576 patients with recurrent asthma exacerbations and evidence of eosinophilic inflammation...
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ژورنال
عنوان ژورنال: Expert Review of Clinical Immunology
سال: 2011
ISSN: 1744-666X,1744-8409
DOI: 10.1586/eci.11.27